The Mechanisms of Toxicity of Dibutyl Phthalate (DBP) in Cultured Cells

The Mechanisms of Toxicity of Dibutyl Phthalate (DBP) in Cultured Cells

The mechanisms of toxicity of Dibutyl Phthalate (DBP) in cultured cells.

Semantic Scholar extracted view of "The mechanisms of toxicity of Dibutyl Phthalate (DBP) in cultured cells." by Nicholas Mckitterick Using urinary metabolites, this work successfully identified workplaces with likely occupational phthalate exposure and found [Toxicity of dibutyl phthalate in primary cultured rat hippo Objective: To investigate the neurotoxicity and toxicological mechanism of dibutyl phthalate (DBP) in primary cultured rat hippocampal neurons. Methods: Primary rat hippocampal neurons cultured for 4 days were exposed to 1 g/L DBP for 24, 48, or 96 h.

action and human relevance evaluation of Dibutyl Phthalate

Dibutyl phthalate (DBP) is used as a plasticizer in a variety of commercial and consumer products (US EPA, 2014; Kavlock et al. 2002). The largest source of DBP exposure in humans is food, with inhalation Comparative toxicity of the plasticizer dibutyl phthalate to Therefore, the acute toxic effects and underlying mechanisms of dibutyl phthalate (DBP) at different concentrations (0-20mgL-1) on two typical freshwater algae (Scenedesmus obliquus and Chlorella pyrenoidosa) were investigated. The growth of S. obliquus and-1

The mechanisms of toxicity of Dibutyl Phthalate (DBP) in cultured cells

The mechanisms of toxicity of Dibutyl Phthalate (DBP) in cultured cells. By Nicholas McKitterick Abstract The ubiquitous environmental pollutant Dibutyl Phthalate (DBP) is a known to have anti-androgenic like properties. DBP exposure has been linked to a Dibutyl Phthalate – Toxicity SummaryDBP induced proliferation in estrogen-responsive breast cancer cell lines MCF-7 and ZR-75. ANIMAL STUDIES: The profile of effects following exposure to DBP is similar to that of other phthalate esters, which, in susceptible species, can induce hepatomegaly, increased numbers of hepatic peroxisomes, fetotoxicity, teratogenicity, and testicular damage.

action and human relevance evaluation of Dibutyl Phthalate

Dibutyl phthalate (DBP) is used as a plasticizer in a variety of commercial and consumer products (US EPA, 2014; Kavlock et al. 2002). The largest source of DBP exposure in humans is food, with inhalation OF CURRENT EVIDENCE ON THE REPRODUCTIVE TOXICITY OF DIB Over the past years, many legitimate concerns have been raised about the effects of dibutyl phthalate (DBP) as an endocrine disruptor, especially on reproduction. The aim of this publication is to critically review the literature related to the developmental and reproductive toxicity of DBP in ani-

The mechanisms of toxicity of Dibutyl Phthalate (DBP) in cultured cells

The mechanisms of toxicity of Dibutyl Phthalate (DBP) in cultured cells. By Nicholas McKitterick Abstract The ubiquitous environmental pollutant Dibutyl Phthalate (DBP) is a known to have anti-androgenic like properties. DBP exposure has been linked to a Metabolomics-based approach for assessing the toxicity mecha 22/11/2014 · Dibutyl phthalate (DBP) is a ubiquitous contaminant in the marine environment, and relatively little is known about the toxicological mechanisms of this compound at the metabolite level. In this study, marine gastropods (abalone) were exposed to DBP at environmentally relevant concentrations (2, 10, and 50 μg/L) for 30 days. The plasma metabolite profiles were determined at the 5th, 15th, and

Acute toxicity and responses of antioxidant systems to dibut

Dibutyl phthalate (DBP) is the most frequently reported PAE pollutant, and has been detected in a variety of water sources and sediments (Huang, Sun & Song, 1999). High levels of DBP were reported in the South African Songhua River (3.42–10.2 mg/L) (Fatoki et OF CURRENT EVIDENCE ON THE REPRODUCTIVE TOXICITY OF DIB DIBUTYL PHTHALATE REPROTOXICITY REVIEW REVIEW P APER IJOMEH 2021;34(1) 17 In therabbits treated with DBP at adose of 400 mg/kg bw/day (given via gavage for 8 weeks) increased liver weight, degen-eration and atrophy of the seminiferous tubules

The mechanisms of toxicity of Dibutyl Phthalate (DBP) in cultured cells

The mechanisms of toxicity of Dibutyl Phthalate (DBP) in cultured cells. By Nicholas McKitterick Abstract The ubiquitous environmental pollutant Dibutyl Phthalate (DBP) is a known to have anti-androgenic like properties. DBP exposure has been linked to a Is dibutyl phthalate harmful? – Greedhead.net26/10/2019 · Is dibutyl phthalate harmful? Dibutyl phthalate is used in making flexible plastics that are found in a variety of consumer products. It appears to have relatively low acute (short-term) and chronic (long-term) toxicity. EPA has classified dibutyl phthalate as a Group D, not classifiable as to human carcinogenicity.

OF CURRENT EVIDENCE ON THE REPRODUCTIVE TOXICITY OF DIB

DIBUTYL PHTHALATE REPROTOXICITY REVIEW REVIEW P APER IJOMEH 2021;34(1) 17 In therabbits treated with DBP at adose of 400 mg/kg bw/day (given via gavage for 8 weeks) increased liver weight, degen-eration and atrophy of the seminiferous tubules Combined Effects of Dibutyl Phthalate (DBP) and Benzo(a)Pyre In this study, we investigated whether the reproductive toxicity of Bap and DBP can affect the male fertility and explored the possible mechanisms. Our study provides strong evidences for the toxic effects of Bap and DBP on male fertility. 2. Methods 2.1. Animals

Is dibutyl phthalate harmful? – Greedhead.net

26/10/2019 · Is dibutyl phthalate harmful? Dibutyl phthalate is used in making flexible plastics that are found in a variety of consumer products. It appears to have relatively low acute (short-term) and chronic (long-term) toxicity. EPA has classified dibutyl phthalate as a Group D, not classifiable as to human carcinogenicity. Acute toxicity and responses of antioxidant systems to dibut 25/11/2018 · Dibutyl phthalate (DBP) poses a severe threat to aquatic ecosystems, introducing hazards to both aquatic species and human health. The ecotoxic effects of DBP on aquatic organisms have not been fully investigated. This study investigates acute toxicity, oxidative

In vitro genotoxicity of dibutyl phthalate on A549 lung cell

11/10/2021 · To evaluate potential adverse health effects of phthalates upon inhalation exposure, the current study evaluated DBP toxicity in human A549 alveolar-like cells at the ALI. It showed that DBP induces oxidative stress and exerts genotoxic effects on the lung cells Toxicology and Industrial Health Short-term toxicity of dibu Article Short-term toxicity of dibutyl phthalate to mice intestinal tissue Jimian Yu1, Wei Wang2, Jianfeng Wang3, Chun Wang3 and Caiyan Li2 Abstract The objective of this study was to investigate changes in intestinal histopathology and expression of heat-shock